亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
97人妻成人免费视频,奇米第四狠狠777高清秒播,搡女人免费免费视频观看
Rabbit Anti-PIAS4/PIASy /AP Conjugated antibody (bs-23480R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-23480R-AP
英文名稱 Rabbit Anti-PIAS4/PIASy /AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的激活STAT蛋白抑制因子4抗體
別    名 E3 SUMO protein ligase PIAS4; E3 SUMO-protein ligase PIAS4; FLJ12419; MGC35296; PAIASgamma; PIAS 4; PIAS gamma; PIAS-gamma; PIAS4; PIAS4_HUMAN; PIASG; PIASgamma; PIASy; Protein inhibitor of activated STAT 4; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; Protein inhibitor of activated STAT protein PIASy; Zinc finger MIZ type containing 6; ZMIZ 6; ZMIZ6.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  細(xì)胞凋亡  生長因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Chicken, Pig, Cow, Horse, Zebrafish, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PIAS4/PIASy
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Constituents: 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3, 50% glycerol. Or Lyophilized. Buffer = 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3. Reconstitute with sterile distilled water.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The IL-6-type family of cytokines, which includes IL-6 and a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. Transcription factors of the STAT family are involved in IL-6 family-mediated signal transduction pathways, and upon activation undergo phosphorylation, dimerization and translocation to the nucleus. The duration and intensity of a cell's response to cytokines can be adjusted by the effect of several regulatory mechanisms. One example involves the protein inhibitor of activated signal transducer and activator of transcription (STAT) family (PIAS family) of proteins, which act as negative regulators of STATs in cytokine signaling. PIAS proteins are able to coactivate steroid receptor-dependent transcription as well. Human PIASy is a 510 amino acid transcriptional corepressor of the androgen receptor (AR). In addition, PIASy may regulate p53-mediated events and may direct p53 into a transactivation-independent mode of apoptosis.

Function:
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.

Subcellular Location:
Nucleus > PML body. Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.

Tissue Specificity:
Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes.

Post-translational modifications:
Sumoylated. Lys-35 is the main site of sumoylation. Sumoylation is required for TCF4 sumoylation and transcriptional activitation. Represses LEF1 transcriptional activity. SUMO1 is the preferred conjugate.

Similarity:
Belongs to the PIAS family.
Contains 1 PINIT domain.
Contains 1 SAP domain.
Contains 1 SP-RING-type zinc finger.

Database links:

Entrez Gene: 51588 Human

Entrez Gene: 59004 Mouse

Entrez Gene: 362827 Rat

Omim: 605989 Human

SwissProt: Q8N2W9 Human

SwissProt: Q3UGQ2 Mouse

SwissProt: Q9JM05 Mouse

Unigene: 105779 Human

Unigene: 34428 Mouse

Unigene: 12810 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
成人午夜又粗又硬又长 | 91人妻精品一区二区三区蜜桃 | 在线观看亚洲中文字幕 | 国产精一品亚洲二区在线播放 | 很黄很黄地在床视频女 | 日本在线电影一区二区三区 | 国产美女精品一区二区三区 | 日韩人欧美?片内射∵久久中国 | 国产精品va在线观看浪潮 | 91嫖妓站街按摩店老熟女 | 国产午夜激无码Av片在线观看 | 成人网站免费大全日韩国产 | 欧美日韩激情在线一区二区三区 | 男女无套内射白将在线线国语 | 2019香蕉在线观看直播视频 | 调教羞辱双飞娇嫩校花 | 久久er热在这里只有精品66 到这里 | 秋葵视频ios无限制解码免费版下载 | 大学生一级毛片全黄真人无码 | 猛烈的抽插她丰满白嫩 | 欧美三级在线电影免费 | 亚洲成人在线免费观看 | 欧美操片在线观看 | 九九综合VA免费看 | 亚洲一级毛片免观看 | 无码一区二区三区亚洲人妻 | 熟女少妇一区二区三区 | 国产黑丝一区二区 | 超碰高清人人爽久久人人 | 亚洲国产美女视频 | 精品国产一区二区三区无码黄 | 蜜臀久久久久精品久久久 | 麻豆精产国品免费免费观看高清 | 亚洲欧美日本韩国 | 色偷偷偷久久伊人大杳蕉 | 欧美人与禽z0zo牲伦交 | 滋润BBWWBWWBBWW | 伊人色综合久久天天人守人婷 | 免费精品国产日韩热久久 | 2019香蕉在线观看直播视频 | 10000部拍拍拍免费视频 |