亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲日韩精品一区二区二,色欲av伊人久久大香线蕉影院,国产在线视频欧美一区二区三区
Rabbit Anti-Hepatitis A virus polyprotein VP1 /BF488 Conjugated antibody (bs-10624R-BF488)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-10624R-BF488
英文名稱 Rabbit Anti-Hepatitis A virus polyprotein VP1 /BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的甲型肝炎病毒聚蛋白VP1抗體
別    名 polyprotein; POLG_HAVMB; Genome polyprotein; Protein VP1-2A; Protein VP1.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  細(xì)菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23/38/245kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Hepatitis A virus polyprotein VP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Hepatitis A virus (HAV) is classified with the enterovirus group of the Picornaviridae family. Many other picornaviruses cause human disease, including polioviruses, coxsackieviruses, echoviruses, and rhinoviruses (cold viruses). The term hepatitis A (HA) or type A viral hepatitis has replaced all previous designations: infectious hepatitis, epidemic hepatitis, epidemic jaundice, catarrhal jaundice, infectious icterus, Botkins disease, and MS-1 hepatitis.

Function:
Capsid proteins VP1, VP2, and VP3 form a closed capsid enclosing the viral positive strand RNA genome. All these proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid (T=3) composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes. The capsid interacts with HAVCR1 to provide virion attachment to target cell.
VP0 precursor is a component of immature procapsids. The N-terminal domain of VP0, protein VP4, is needed for the assembly of 12 pentamers into the icosahedral structure. Unlike other picornaviruses, HAV VP4 does not seem to be myristoylated and has not been detected in mature virions, supposedly owing to its small size.
VP1-2A precursor is a component of immature procapsids and corresponds to an extended form of the structural protein VP1. The C-terminal domain of VP1-2A, protein 2A, acts as an assembly signal that allows multimerization of VP1-2A and formation of pentamers of VP1-VP2-VP3 trimers. It is proteolytically removed from the precursor by a host protease and does not seem to be found in mature particles (By similarity).
Protein 2B and 2BC precursor affect membrane integrity and cause an increase in membrane permeability (By similarity).
Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities.
Protein 3A, via its hydrophobic domain, serves as membrane anchor to the 3AB and 3ABC precursors.
The 3AB precursor interacts with the 3CD precursor and with RNA structures found at both the 5'- and 3'-termini of the viral genome. Since the 3AB precursor contains the hydrophobic domain 3A, it probably anchors the whole viral replicase complex to intracellular membranes on which viral RNA synthesis occurs.
The 3ABC precursor is targeted to the mitochondrial membrane where protease 3C activity cleaves and inhibits the host antiviral protein MAVS, thereby disrupting activation of IRF3 through the IFIH1/MDA5 pathway. In vivo, the protease activity of 3ABC precursor is more efficient in cleaving the 2BC precursor than that of protein 3C. The 3ABC precursor may therefore play a role in the proteolytic processing of the polyprotein.
Protein 3B is covalently linked to the 5'-end of both the positive-strand and negative-strand genomic RNAs. It acts as a genome-linked replication primer (By similarity).
Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease. Also cleaves host proteins such as PCBP2.
RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals.

Subunit:
3AB precursor is a homodimer. 3AB precursor interacts with 3CD precursor. Protein 3ABC interacts with human MAVS.

Subcellular Location:
Protein VP1: Virion. Host cytoplasm (Potential).
Protein VP1-2A: Virion. Host cytoplasm (Potential).

Post-translational modifications:
Specific enzymatic cleavages by the viral protease in vivo yield a variety of precursors and mature proteins. Polyprotein processing intermediates are produced, such as P1-2A which is a functional precursor of the structural proteins, VP0 which is a VP4-VP2 precursor, VP1-2A precursor, 3ABC precursor which is a stable and catalytically active precursor of 3A, 3B and 3C proteins, 3AB and 3CD precursors. The assembly signal 2A is removed from VP1-2A by a host protease. During virion maturation, non-infectious particles are rendered infectious following cleavage of VP0. This maturation cleavage is followed by a conformational change of the particle (By similarity). [PTM] VPg is uridylylated by the polymerase and is covalently linked to the 5'-end of genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).

Similarity:
Belongs to the picornaviridae polyprotein family.
Contains 1 peptidase C3 domain.
Contains 1 RdRp catalytic domain.
Contains 1 SF3 helicase domain.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
日韩mv国产mv网站永久 | 精品久久久久久精品中文字幕无码 | 亚洲欧美日韩国产专区一区 | www.国产精品.com | 少妇真人直播免费视频 | 亚洲国产精品嫩草影院在线观看 | 亚洲国产欧美另类 | 亚洲中文字幕在线第六区 | 成人片在线观看地址KK4444 | 国产伦精品一区二区三区精品 | 717影院理论午夜伦八戒 | 精品久久久久久久久久中文字幕 | 50岁寡妇下面水多好紧 | 欧美成人一区二区三区片免费 | 宝贝乖调教跪趴SM主人玩具HH | 粉嫩国产15xxxxx | 精品久久久久久无码人妻热蜜芽 | 国产深夜福利在线观看网站 | 午夜欧美日韩国产福利91不卡一区二区三区 | 强行内射无码毛片视频 | 欧美午夜精品久久久久久浪潮 | 久久国内精品自在自线 | 91精品国产色综合久久不卡美美 | 欧美亚洲另类丝袜自拍动漫 | 国产成人精品无缓存在线播放 | 国产欧美日产综合网中文 | 女被男啪到哭的视频网站免费 | 久久精品中文闷骚内射 | 国产精品黄在线观看免费网站 | 国产精品免费看久久久8 | 又大又粗欧美黑人AAAAA片 | 新普新京亚洲欧美日韩国产 | 2021国产麻豆剧传媒免费下载 | 国产乱婬AV一区二区三区 | 日韩欧美国产中文字幕 | 亚洲国产一区二区三区AV | 又粗又大又黄的少妇毛片 | 欧美乱妇狂野欧美在线视频 | 丰满少妇被猛男猛烈进入久久 | 乱码一二三乱码又大又粗 | 无码狠狠躁久久久久久久 |