亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美高清videosex,日本xXXx色视频在线播放,国产成人AV激情在线播放
Mouse Anti-EpCAM/BF594 Conjugated antibody (bsm-51174M-BF594)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bsm-51174M-BF594
英文名稱 Mouse Anti-EpCAM/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的小鼠抗上皮細(xì)胞粘附分子單克隆抗體
別    名 Adenocarcinoma associated antigen; CD326; CD326 antigen; Cell surface glycoprotein Trop 1; CO17 1A; EGP; EGP40; Ep CAM; Epithelial cell surface antigen; Epithelial cellular adhesion molecule; Epithelial glycoprotein; GA733 2; hEGP 2; KS 1/4 antigen; KSA; Lymphocyte antigen 74; M1S2; M4S1; Major gastrointestinal tumor associated protein GA733 2; MIC18; MK 1; TACD1; TACSTD1; TROP1; Tumor associated calcium signal transducer 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  細(xì)胞粘附分子  細(xì)胞表面分子  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 10A8
交叉反應(yīng) (predicted: Human, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EpCAM
亞    型 IgG1
純化方法 affinity purified by Protein G
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]

Function:
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.

Subunit:
Monomer. Interacts with phosphorylated CLDN7.

Subcellular Location:
Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Co-localizes with CLDN7 at the lateral cell membrane and tight junction.

Tissue Specificity:
Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.

Post-translational modifications:
Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.

DISEASE:
Defects in EPCAM are the cause of diarrhea type 5 (DIAR5) [MIM:613217]. It is an intractable diarrhea of infancy characterized by villous atrophy and absence of inflammation, with intestinal epithelial cell dysplasia manifesting as focal epithelial tufts in the duodenum and jejunum. Defects in EPCAM are a cause of hereditary non-polyposis colorectal cancer type 8 (HNPCC8) [MIM:613244]. HNPCC is a disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. Note=HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.

Similarity:
Belongs to the EPCAM family.
Contains 1 thyroglobulin type-1 domain.

Database links:

Entrez Gene: 4072 Human

Entrez Gene: 17075 Mouse

Entrez Gene: 171577 Rat

Omim: 185535 Human

SwissProt: P16422 Human

SwissProt: Q99JW5 Mouse

SwissProt: O55159 Rat

Unigene: 542050 Human

Unigene: 4259 Mouse

Unigene: 106481 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
亚洲日本欧美产综合在线 | 真人与拘做受免费视频 | 国产后进白嫩翘臀在线动漫 | 久久免费精品高清麻豆 | 无码A级毛片日韩精品 | 高清一区二区三区日本久 | 99精品一级欧美片免费播放 | 久久久久久精品毛片A级按摩 | 国产呦精品一区二区三区下载 | 欧美全透明薄纱无内衣秀 | 国产精品xxx电影 | 五月天婷五月天综合网 | 国产精品福利在线播放 | 国产欧美日韩精品一区二区三区蜜桃不卡 | 亚洲欧美日韩在线观看 | 欧美日韩精品视频一区二区三区在线观看 | 少妇性荡欲午夜性开放视频剧场 | 午夜成人性爽爽免费视频 | 国产日韓无码一区二区三区久久区 | 高清国产激情视频在线观看 | 91久久精品无码一级毛片 | 久久精品无码鲁网中文电影 | 日韩AV在线高清免费毛片 | 国产对白国语对白 | 很很鲁很很在线视频97 | 天堂中文在线最新版WWW | 国产精品自在拍在线播放 | 丰满少妇被猛烈进入毛片 | 色国产在线视频一区 | 欧美日韩亚洲一区二区三区在线观看 | 欧美精品综合视频一区二区 | 在线精品自偷自拍无码 | 国产精品扒开腿做爽爽爽视频 | 影音先锋亚洲AV少妇熟女 | 午夜婷婷一夜七次郎 | 无码人妻精品一区二区中文 | 捣烂宫口np失禁哭张开了h | 4455永久在线毛片观看 | 好大好硬好爽好深好硬视频 | 欧美一区二区精品久久久 | 国产精品户露AV在线户外直播 |